Hypertension from NSAID use

by Nathan Wei, MD, FACP, FACR

Nathan Wei is a nationally known board-certified rheumatologist and author of the Second Opinion Arthritis Treatment Kit. It's available exclusively at this website... not available in stores.

Click here: Second Opinion Arthritis Treatment Kit

Non-steroidal anti inflammatory drugs (NSAIDS) are used commonly to treat the symptoms of arthritis.

Unfortunately, the method by which they work to block inflammation is also a reason they are responsible for potentially serious side-effects.

While gastrointestinal bleeding due to gastric ulcers (ulcers in the stomach) are one of the more serious problems, another bothersome adverse event is hypertension.

This is primarily due to one major problem which is activation of the angiotensin system. This system, which is primarily based in the kidney, is responsible for maintenance of normal blood pressure.

NSAIDS lead to reduced kidney blood flow. This causes the angiotensin system to increase blood pressure and circulating hormonal factors are released in order to do that. The effects are:

• Retention of salt and water
• Increased squeezing down of arteries

The net effect is an elevation of blood pressure.

In addition to blood pressure increases, NSAIDS can also lead to edema in the legs. Blood pressure elevation is one of the main contributors to stroke and heart attack.

Get more information about hypertension from NSAID use and related issues as well as...

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