Fibromyalgia and substance P
by Nathan Wei, MD, FACP, FACR
Nathan Wei is a nationally known board-certified rheumatologist and author of the Second Opinion Arthritis Treatment Kit. It's available exclusively at this website... not available in stores.
Click here: Second Opinion Arthritis Treatment Kit
Fibromyalgia (FM) is one of the most common musculoskeletal conditions seen by rheumatologists.
It is characterized by a history of generalized aches and pains, chronic fatigue, non restorative sleep (the patient feels tired even after sleeping all night), and the presence of multiple tender trigger points on examination.
Patients with fibromyalgia exhibit allodynia (severe pain with a normal stimulus) and allopathia (a hyper normal response to pain). A more detailed discussion may be found in the FM section of this website.
Causes of FM are still unknown. Serotonin and dopamine, two neurotransmitters in the brain are mentioned as possibly being involved.
Decreased blood flow to certain area of the brain responsible for pain perception and modulation of pain signaling have also been seen.
Substance P is a tachykinin, a peptide (protein) that has biological activity as a pain inducer. Studies have indicated that patients with FM have elevated levels of Substance P in the serum, urine, spinal fluid, and soft tissues.
Other tachykinins such as melatonin, tryptophan, nerve growth factors, and kyneurenine may also have various roles. Prostaglandins and corticotrophin releasing hormone (CRH) also seem to be implicated.
Different receptors for tachykinins have also been discovered. One such receptor, NK1, may be an important player in FM. When blockade of this receptor is performed, symptoms appear to improve.
Get more information about fibromyalgia and substance p and related issues as well as...
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• Ignored remedies that eliminate fibromyalgia symptoms quickly!
• Obsolete treatments for knee osteoarthritis that still are used... and may still work for you!
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• And much more...
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