Febuxostat gout

by Nathan Wei, MD, FACP, FACR

Nathan Wei is a nationally known board-certified rheumatologist and author of the Second Opinion Arthritis Treatment Kit. It's available exclusively at this website... not available in stores.

Click here: Second Opinion Arthritis Treatment Kit

This drug is a non-purine xanthine oxidase inhibitor under FDA review for treatment of hyperuricemia in gout.

It is a urate lowering drug which, hopefully, won’t cause hypersensitivity.

Side effects noted in clinical trials include:

• Liver function tests
• Headache
• Abdominal pain
• Dizziness

Also, there has been some concern regarding potential cardiovascular side effects.

There was a 75% median reduction in tophus size over 52 weeks with febuxostat when the serum uric acid was kept below 6.0 mg/dL.

Because of the relative toxicity of allopurinol as well as the ineffectiveness of probenecid in many patients, febuxostat is viewed as a potentially valuable treatment for gout.

Another therapy that is undergoing trial is PEG-uricase. This is a drug that converts uric acid to allantoin, a seemingly harmless product. It is administered via intravenous infusion.

Get more information about febuxostat gout and related issues as well as...

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